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The safety and efficacy of prograf with sirolimus has not been established in kidney transplant see warnings and precautions .

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Prograf is indicated for the prophylaxis of organ rejection in patients receiving allogeneic heart transplantsIt is recommended that Prograf be used concomitantly with azathioprine or mycophenolate mofetilMMFand adrenal corticosteroidssee Clinical StudiesTherapeutic drug monitoring is recommended for all patients receiving Prografsee DOSAGE AND ADMINISTRATION

ISMP Canada gratefully acknowledges the expert review of this article byin alphabetical orderPatti CornishRPhBScPhmPatient Safety ServiceSunnybrook Health Sciences CentreJennifer HarrisonBScPhmMScPharmacy Clinical Site LeaderUniversity Health NetworkNicola RosaasenBScBSPPharmacistSaskatchewan Transplant ProgramJeffrey SchiffMDFRCPCMulti-Organ Transplant ProgramToronto General HospitalJohn W SendersPhDProfessor EmeritusUniversity of TorontoAnita WongBScPharmRexall Outpatient PharmacyUniversity of Alberta Hospitaland Ken WouBSc(Pharmpharmacy consultant.

Pediatric liver transplantation patients without pre-existing renal or hepatic dysfunction have required and tolerated higher doses than adults to achieve similar blood concentrations.

This drug may increase yourpotassium levelsBefore using potassium supplements or salt substitutes containing potassiumconsult your doctor or pharmacist.

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if you have diarrhoea for more than one day, please tell your doctor, because it might be necessary to adapt the dose of prograf that you receive.

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